Guillain-Barré syndrome triggered by surgery in a Chinese population: a multicenter retrospective study

Abstract Background Surgery is a potential trigger of Guillain-Barré syndrome (GBS), disorder which leads to an autoimmune-mediated attack peripheral nerves. The present study was designed explore clinical features post-surgical GBS compared with those general in order provide better advice patients undergoing surgery. Methods medical records who were seen at 31 tertiary hospitals southern China between January 1, 2013 and September 30, 2016 retrospectively analyzed. Post-surgical defined as symptoms within 6 weeks after Clinical are described GBS. Results Among the 1001 patient cases examined this study, 45 (4.5%) exhibited Within group, 36 (80.0%) developed initial limb weakness. average interval surgery symptom onset 13.31 days. most common type triggered orthopedic surgery, followed by neurological Compared GBS, characterized higher proportion severe (Hughes functional grading scale (HFGS) score ≥ 3) upon admission nadir, HFGS scores discharge, longer hospital stays. also had significantly frequency acute motor axonal neuropathy subtype (37.9 vs. 14.2, respectively; P = 0.001). Conclusion probably factor for especially Infections secondary may play role. possibility preceding (post-operative) infections not excluded study. presentation more course poorer prognosis, should be closely monitored. Trial registration chicTR-RRc-17,014,152 .